(一)主持的科研项目 [1] 国家自然科学基金青年科学基金项目:蛋氨酸限制饮食调控肠内H2S与丁酸互作改善肠粘膜屏障的分子机制(32502230),2026-2028,主持,在研。 [2] 中国博士后科学基金面上项目:可降低机体蛋氨酸水平的乳酸菌筛选及其肠道中降解机制研究(2023M730977),2023-2025,主持,在研。 [3] 河南省重点研发与推广专项(科技攻关)项目:降解蛋氨酸乳酸菌在酸奶发酵中的应用研究(232102110154),2023-2024,主持,结项。 [4] 河南省科技研发计划联合基金(应用攻关类)项目:低蛋氨酸主食面制品加工的关键技术研发及应用(222103810062),2023-2024,主持,结项。 [5] 河南省高等学校重点科研项目指导计划项目:膳食蛋氨酸限制通过肠道菌群调控机体氧化三甲胺生成的机理研究(22A550002),2022-2023,主持,结项。 [6] 郑州千味央厨食品股份有限公司:食品中氨基酸组成调控技术及相关功能性食品创制(H2025140LY-0315),2025-2027,主持,在研。 [7] 宁陵县宸宇食品有限公司:低蛋氨酸膨化零食加工关键技术研发及产品创制(H2025120LY-0552),2025-2029,主持,在研。 (二)代表著作与论文(近五年主要成果) [1] Hao Yang, Yuhui Yang*(通讯作者), Jing Qian, Wenying Hu, Jinjie Liu, Fred Mwabulili, Peng Li, Yanli Xie. Dietary methionine restriction ameliorates ulcerative colitis in mice: A role for the H₂S and short-chain fatty acids balance via gut microbiota remodeling. Food Research International, 2026, 233: 119038.(中科院一区TOP) [2] Yuhui Yang, Yanli Xie*, Ru Liu, Xiaojie Cui, Changtong Cui, Qiaofen Cheng, Peng Li, Renyong Zhao. Characteristic of different thermal treatment-induced dough protein oxidation and its impact on human gut microbiota. Current Research in Food Science, 2026, 12: 101357.(中科院一区TOP) [3] Yuhui Yang, Yanli Xie*, Manman Lu, Yuncong Xu, Renyong Zhao. Contribution of dietary methionine to gut health and its related diseases: implications for precision nutrition. Critical Reviews in Food Science and Nutrition, 2026, 66(3): 565–588.(中科院一区TOP) [4] Yuhui Yang, Yilong Hu, Xiaojie Cui, Liuqing Li, Ru Liu, Fred Mwabulili, Yanli Xie*, Peng Li*. Ameliorating effects of anthocyanin addition on protein oxidation and its induced intestinal microbiota disturbance in spray-dried milk powder. Journal of Agriculture and Food Research, 2026, 26: 102511.(中科院二区TOP) [5] Keying Chu, Xiaojie Cui, Yuhui Yang*(通讯作者), Qiong Wu, Ru Liu, Yanli Xie. Effects of pressure cooker treatment-induced protein oxidation of cereals on human gut microbiota using an in vitro fermentation model. Food Research International, 2025, 220: 117123.(中科院一区TOP) [6] Yuncong Xu, Yuhui Yang*(通讯作者), Yuge Jiang, Bowen Li, Yanli Xie, Yonghui Shi, Guowei Le. Dietary methionine regulation of cognitive function: Evidence, mechanisms, and implementation strategies. Food Research International, 2025, 219: 116858.(中科院一区TOP) [7] Qiong Wu, Xiaojie Cui, Yuhui Yang*(通讯作者), Keying Chu, Ru Liu, Sijin Gao, Yanli Xie. Effects of refrigeration-induced protein oxidation of rice and wheat steamed bread on the human gut microbiota in an in vitro fermentation model. LWT-Food Science and Technology, 2025, 222: 117657.(中科院一区TOP) [8] Hao Yang, Yuhui Yang*(通讯作者), Guifang Cui, Yuncong Xu, Renyong Zhao, Guowei Le, Yanli Xie, Peng Li. Dietary methionine restriction ameliorates atherosclerosis by remodeling the gut microbiota in apolipoprotein E-knockout mice. Food & Function, 2025, 16, 4904–4922.(中科院一区TOP) [9] Jinjie Liu, Yuhui Yang*(通讯作者), Nazish Muzaffar, Hao Yang, Xiao Li, Yanli Xie*, Peng Li. Screening, identification, and evaluation of lactic acid bacteria for branched-chain amino acids degradation. Journal of Future Foods, 2025, DOI: https://doi.org/10.1016/j.jfutfo.2025.09.025.(中科院一区TOP) [10] Yuncong Xu, Yuhui Yang*(通讯作者), Yonghui Shi, Bowen Li, Yanli Xie, Guowei Le. Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging mice. npj Science of Food, 2024, 8: 104.(中科院一区TOP) [11] Yang Yuhui, Cui Guifang, Qian Jing, Yuncong Xu, Bowen Li, Yonghui Shi, Guowei Le, Yanli Xie*. Fecal microbiota transplantation from methionine-restricted diet mouse donors reduces fat deposition in obese mice by remodeling the gut microbiota. Food Bioscience, 2024, 59: 104255. (中科院一区TOP) [12] Yuhui Yang, Hao Yang, Xu Tian, Wenhan Jian, Nazish Muzaffar, Guowei Le, Yanli Xie, Peng Li*, Yuncong Xu*. Fish collagen peptides supplementation ameliorates skeletal muscle injury in high-fat diet mice associated with thyroid function recovery. Journal of Functional Foods, 2024, 123: 106612.(中科院二区TOP) [13] Bowen Li, Yuhui Yang*(通讯作者), Yinyi Ding, Yueting Ge, Yuncong Xu, Yanli Xie, Yonghui Shi, Guowei Le. Dityrosine in food: A review of its occurrence, health effects, detection methods, and mitigation strategies. Comprehensive Reviews in Food Science and Food Safety, 2023, 22: 355–379. (中科院一区TOP) [14] Yang Yuhui, Lu Manman, Jing Qian, Yuncong Xu, Bowen Li, Guowei Le, Yanli Xie*. Dietary methionine restriction promotes fat browning and attenuates hepatic lipid accumulation in high choline-fed mice associated with the improvement of thyroid function. Journal of Agricultural and Food Chemistry, 2023, 71(3): 1447–1463. (中科院一区TOP, 封面论文) [15] Yang Yuhui, Lu Manman, Xu Yuncong, Jing Qian, Guowei Le, Yanli Xie*. Dietary methionine via dose-dependent inhibition of short-chain fatty acid production capacity contributed to a potential risk of cognitive dysfunction in mice. Journal of Agricultural and Food Chemistry, 2022, 70(48): 15225−15243. (中科院一区TOP, 封面论文) [16] Xu Yuncong, Yuhui Yang*(通讯作者), Bowen Li, Yanli Xie, Yonghui Shi, Guowei Le. Dietary methionine restriction improves gut microbiota composition and prevents cognitive impairment in D-galactose-induced aging mice. Food & Function, 2022, 13: 12896−12914. (中科院一区TOP) [17] Yang Yuhui, Lu Manman, Xu Yuncong, Jing Qian, Guowei Le, Yanli Xie*. High dietary methionine intake may contribute to the risk of nonalcoholic fatty liver disease by inhibiting hepatic H2S production. Food Research International, 2022, 158: 111507. (中科院一区TOP) [18] 杨浩, 崔桂芳, 鲁嫚嫚, 王亚新, 谢岩黎, 杨玉辉*(通讯作者). 含硫氨基酸对代谢健康的影响及其检测方法研究进展. 食品科学, 2025, 46(11): 364−374.(EI收录) [19] 钱静, 杨玉辉*(通讯作者), 崔桂芳, 谢岩黎. 蛋氨酸限制饮食对小鼠酒精性脂肪肝的改善作用. 中国食品学报, 2025, 25(3): 187−197.(EI收录) [20] 鲁嫚嫚, 钱静, 杨玉辉*(通讯作者), 谢岩黎, 乐国伟. 蛋氨酸限制饮食的健康益处及其实现策略研究进展. 食品科学, 2023, 44(11): 367−378.(EI收录) |
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