
何保山,博士、教授、河南省教育厅学术技术带头人、河南省高等学校青年骨干教师,入选全球前 2%顶尖科学家年度科学影响力榜单和终身科学影响力排行榜单。主要从事粮油食品安全快速检测、传感器技术及健康食品创制等方面研究。近年来主持完成国家级、省部级、地厅级课题共20余项;目前已在 Anal. Chem.、Food Chem.、Biosens. Bioelectron.、Chem. Eng. J.等国际知名期刊上发表论文150余篇,TOP期刊文章80余篇,被引2000余次,H 因子26。授权国家发明专利 26 项,获河南省科学技术进步奖二等奖 3 项(主持 1 项),河南省教育厅科技成果奖一等奖 3 项。先后获国家级教学成果奖二等奖、河南省教育厅教学成果奖特等奖、河南省优秀硕士学位论文指导教师、河南省教育系统教学技能竞赛一等奖、河南省教学标兵称号等奖励荣誉称号。
通讯地址:河南省郑州市高新区莲花街100号粮油食品学院8528室
联系电话:15037187035/18623717765
电子邮箱:hebaoshan@126.com
学术兼职
河南省食品科学技术学会理事
农产品食品检验员培训首席专家
河南省食品安全协会食品安全专家
全国研究生教育评估监测专家库专家
受邀担任Anal. Chem.、Food Control、Food Chem、ACS Appl. Mater. Interfaces、Biosens. Bioelectron.、Chem. Eng. J.、J. Hazard. Mater.、Sensor. Actuat. B-Chem.、Talanta、Microchim. Acta、Anal. Chim. Acta等国际期刊审稿专家。
教育与工作经历
2019年-至 今,河南工业大学,粮油食品学院,教授
2012年-2019年,河南工业大学,粮油食品学院,副教授
2008年-2011年,河南工业大学,粮油食品学院,讲师
2005年-2008年, 中国科学院电子学研究所,传感技术国家重点实验室(北方基地),博士研究生/博士
2002年-2005年,武汉大学,化学与分子科学学院,研究生/硕士
1998年-2002年,郑州大学,化工与能源学院,本科/学士
研究领域与方向
粮油食品安全快速检测技术
电化学、光学生物传感器技术
生物识别与功能纳米复合材料设计及合成
健康食品创制
研究成果
(一)主持的科研项目
(1)河南省自然基金面上项目,项目编号:212300410338
(2)河南省高校科技创新人才项目,项目编号:20HASTIT002
(3)河南省高等学校青年骨干教师培养计划,项目编号:2017GGJS072
(4)河南省科技开放合作项目,项目编号:172106000014
(5)国家自然基金青年科学基金项目,项目编号:61301037
(二)代表著作与论文
(1)Biao Jia, Baoshan He, Renli Liu, Jinping Yang, Wenjie Ren, Zhiguang Suo, Yiwei Xu. An aptasensor consisting of the integrated MOF-derived Zn-MOF-on-Co-MOF coupled with AuNPs nanocomposites and aptamer for ultrasensitive assay of fipronil[J]. Food Chemistry, 2025, 470: 142662.
(2)Shi Tang, Baoshan He, Lingling Xie, Xiaoyu Cao, Wenjie Ren, Yiwei Xu. Exploring triplex DNA nanostructures: A comprehensive review from fundamentals to applications [J]. Chemical Engineering Journal, 2025, 505:159425.
(3)Yidan Zhang, Baoshan He, Yurong Zhang, Chunqi Bai, Longdi Wang, Wenhong Zhao, Ligen Wu, Dongdong Xie, Wenjie Ren, Yiwei Xu. An aptasensor based on CRISPR/cas12a-mediated and Mn2+-assisted DNA motor cascade signalling amplification strategy for the detection of T-2 toxin [J]. Sensors and Actuators B: Chemical, 2025, 426: 137049.
(4)Jingyi Zhu, Baoshan He, Yuling Wang, Jinshui Wang, Ying Liang, Huali Jin, Min Wei, Ligen Wu, Wenhong Zhao, Dongdong Xie. Design of a triple-functional polyA-probe: Toward a facile electrochemical aptasensor for vanillin detection [J]. Sensors and Actuators B: Chemical, 2025, 422: 136650.
(5)Mengru Wang, Baoshan He, Lingling Xie, Xiaoyu Cao, Wenjie Ren, Zhiguang Suo, Yiwei Xu, Min Wei, Huali Jin. MOF-derived Mn, N Co-doped Co-C nanomaterials and exo I-driven dual signal amplification for sensitive detection of florfenicol using an electrochemical aptasensor [J]. Chemical Engineering Journal, 2024, 501:157782.
(6)Shi Tang, Baoshan He, Yao Liu, Longdi Wang, Ying Liang, Jinshui Wang, Huali Jin, Min Wei, Huali Jin, Wenjie Ren, Zhiguang Suo, Yiwei Xu. A dual-signal mode electrochemical aptasensor based on tetrahedral DNA nanostructures for sensitive detection of citrinin in food using PtPdCo mesoporous nanozymes[J]. Food Chemistry, 2024, 460: 140739.
(7)Han Yan, Baoshan He, Renyong Zhao, Wenjie Ren, Zhiguang Suo, Yiwei Xu, Dongdong Xie, Wenhong Zhao , Min Wei, Huali Jin. Electrochemical aptasensor based on CRISPR/Cas12a-mediated and DNAzyme-assisted cascade dual-enzyme transformation strategy for zearalenone detection [J]. Chemical Engineering Journal, 2024, 493:152431.
(8)Qianqian Wang, Baoshan He, Yao Liu, Yuling Wang, Huali Jin, Min Wei, Wenhong Zhao, Dongdong Xie, Wenjie Ren, Zhiguang Suo, Yiwei Xu. “Two-in-One”PtPdCu Trimetallic Multifunctional Nanoparticles-Mediated Dual-Signal-Integrated Aptasensor for Ultradetection of Enrofloxacin [J]. ACS Applied Materials & Interfaces, 2024, 16: 22704-22714.
(9)Shi Tang, Baoshan He, Jun Yang, Yao Liu, Ying Liang, Jinshui Wang, Huali Jin, Min Wei, Wenjie Ren, Zhiguang Suo, Yiwei Xu. A signal-amplification electrochemical aptasensor based on porous Pt nanotubes and tetrahedral DNA nanostructures for ultrasensitive detection of citrinin [J]. Sensors and Actuators B: Chemical, 2024, 408: 135519.
(10)Huanhuan Wang, Baoshan He, Jun Yang, Yao Liu, Ying Liang, Jinshui Wang, Huali Jin, Min Wei, Wenjie Ren, Zhiguang Suo, Yiwei Xu. An ultra-sensitive electrochemical aptasensor detection for di(2-ethylhexyl) phthalate based a cleavage effect of Mg2+-driven bipedal DNA walker motor [J]. Sensors and Actuators B: Chemical, 2024, 406: 135412.
(11)Yidan Zhang, Baoshan He, Yuling Wang, Jinshui Wang, Ying Liang, Huali Jin, Min Wei, Wenjie Ren, Zhiguang Suo, Yiwei Xu. Mn2+-Triggered Swing-Arm Robot Strategy Using Anemone-Like Thi@AuPd@Cu-MOFs as Signaling Probes for the Detection of T-2 Toxin[J]. Analytical Chemistry, 2024, 96(1): 92-101.
(12)Weili Qiao, Baoshan He, Jun Yang, Wenjie Ren, Renyong Zhao, Yurong Zhang, Chunqi Bai, Zhiguang Suo Yiwei Xu, Min Wei, Huali Jin. Pt@AuNF nanozyme and horseradish peroxidase-based lateral flow immunoassay dual enzymes signal amplification strategy for sensitive detection of zearalenone [J]. International Journal of Biological Macromolecules, 2024, 254: 127746.
(13)Jia Wu, Baoshan He, Yuling Wang, Renyong Zhao, Yurong Zhang, Chunqi Bai, Min Wei, Huali Jin, Wenjie Ren, Zhiguang Suo, Yiwei Xu. ZIF-8 labelled a new electrochemical aptasensor based on PEI-PrGO/ AuNWs for DON detection [J]. Talanta, 2024, 267: 125257.
(14)Jingyi Zhu, Baoshan He, Yao Liu, Yuling Wang, Jinshui Wang, Ying Liang, Huali Jin, Min Wei, Wenjie Ren, Zhiguang Suo, Yiwei Xu. A novel magneto-mediated electrochemical biosensor integrated DNAzyme motor and hollow nanobox-like Pt@Ni-Co electrocatalyst as dual signal amplifiers for vanilla detection [J]. Biosensors and Bioelectronics, 2023, 241: 115690.
(15)Huanhuan Wang, Baoshan He, Haoyang Yan, Ying Liang, Jinshui Wang, Huali Jin, Min Wei, Wenjie Ren, Zhiguang Suo, Yiwei Xu. RecJf exonuclease-assisted signal amplification for the sensitive detection of di(2-ethylhexyl)phthalate by a Pd@Au NB labeled electrochemical aptasensor based on Au@Ni-CoHNB/PEI-g-C3N4[J]. Journal of Materials Chemistry C, 2022, 10(47): 18040~18051.
(16)Ruina Zheng, Baoshan He, Lingling Xie, Haoyang Yan, Liying Jiang, Wenjie Ren, Zhiguang Suo, Yiwei Xu, Min Wei, Huali Jin. Molecular Recognition-Triggered Aptazyme Sensor Using a CoMOF@MCA Hybrid Nanostructure as Signal Labels for Adenosine Triphosphate Detection in Food Samples [J]. Analytical Chemistry, 2022, 94(37): 12866-12874.
(17)Xia Lu, Baoshan He, Ying Liang, Jinshui Wang, Min Wei, Huali Jin, Wenjie Ren, Zhiguang Suo, Yiwei Xu. Ultrasensitive detection of patulin based on a Ag+-driven one-step dual signal amplification [J]. Journal of Hazardous Materials, 2022, 438: 129491.
(18)Han Yan, Baoshan He, Renyong Zhao, Wenjie Ren, Zhiguang Suo, Yiwei Xu, Yurong Zhang, Chunqi Bai, Haoyang Yan, Renli Liu. Electrochemical aptasensor based on Ce3NbO7/CeO2@Au hollow nanospheres by using Nb.BbvCI-triggered and bipedal DNA walker amplification strategy for zearalenone detection [J]. Journal of Hazardous Materials, 2022, 438: 129491.
(19)Xia Lu, Baoshan He, Ying Liang, Jinshui Wang, Qiang Jiao, Yong Liu, Rui Guo, Min Wei, Huali Jin, Wenjie Ren, Zhiguang Suo. An electrochemical aptasensor based on dual-enzymes-driven target recycling strategy for patulin detection in apple juice [J]. Food Control, 2022, 137: 108907.
(20)Senyao Wang, Baoshan He, Ying Liang, Huali Jin, Min Wei, Wenjie Ren, Zhiguang Suo, Jinshui Wang. Exonuclease III-Driven Dual-Amplified Electrochemical Aptasensor Based on PDDA-Gr/PtPd@Ni-Co Hollow Nanoboxes for Chloramphenicol Detection [J]. ACS Applied Materials & Interfaces, 2021, 13: 26362-26372.
(三)授权发明专利
(1)一种检测玉米赤霉烯酮的比率型电化学传感器制备方法,专利号:ZL 202110084285.1
(2)一种基于内循环放大策略的磺胺喹喔啉电化学适体传感器制备方法,专利号:ZL 202110083613 .6
(3)一种用于硝基呋喃类代谢物残留检测的免疫型电化学传感器制备方法,专利号:ZL 202110121470 .3
(4)一种基于金属离子依赖性DNA酶用于检测邻苯二甲酸二丁酯的电化学免疫传感器制备方法,ZL 202010420081.6
(5)一种用于棒曲霉素检测的电化学适体比率传感器制备方法,专利号:ZL 202010429112.4
(6)一种用于氯霉素含量检测的电化学传感器制备方法,专利号:ZL 202010429399.0
(7)一种用于磺胺类兽药残留检测的电化学传感器制备方法,专利号:ZL 201510044442.0
(8)一种淀粉发酵液中葡萄糖含量的快速检测方法,专利号:ZL 201010522048.0
奖励与荣誉
荣获河南省科学技术进步奖二等奖3项(NO.J 001560、NO.K 003796、NO.J 008678),河南省教育厅科技成果奖一等奖3项(豫教[2020]8175号、豫教[2021]18601号、豫教[2022]21526号)、河南省自然科学优秀学术论文奖二等奖1项(豫人社发〔 2021〕37号)。
先后获得国家级教学成果奖二等奖(教师[2014]8号)、河南省教育厅教学成果奖特等奖(豫教[2013]16676)、河南省高等学校青年骨干教师(豫教[2021]12752)、河南省优秀硕士学位论文指导教师(豫教[2017]04744号、豫教[2021]23325号、豫教[2022]34213号)、河南省教育系统教学技能竞赛一等奖(豫工文〔2018〕82号)、河南省教学标兵称号(豫工文〔2018〕82号)、河南省教育厅学术技术带头人(豫教[2019]00714)等奖励荣誉称号。
实验室和科研团队简介
“健康食品创制及危害检测”团队,本人为团队学术带头人。
团队概述:健康食品创制及危害检测团队成员9人,教授3人,副教授3人,讲师3人;其中博士8人,硕士1人;平均年龄43岁。团队学历层次高、职称结构合理、年富力强、团结协作,富有团队精神,具备了较强的教学、科研能力和较高的专业学术水平。
团队研究方向:团队深耕健康食品创制及危害检测领域,主要围绕食品营养组分评价、营养价值与机体健康作用、现代营养健康食品创制、食品安全快速检测方法及传感技术、现场在线无损检测装备、食品生物分析、食品危害物识别分子筛选方法体系与纳米材料技术等七大重要方向开展有组织的基础及应用研究。
团队主要科研成果:近年来,在食品营养与安全检测、传感器技术研究方面发表SCI论文210余篇,其中,JCR1区论文140余篇,TOP期刊文章100余篇,获批国家级省级以上科研项目18项,授权国家发明专利20余件,获河南省科学技术进步奖二等奖3项,教育厅科技成果奖一等奖4项,国家教学成果奖二等奖1项。