学术兼职

中国粮油学会粮油质检研究分会副会长，中国食品科学技术学会新质蛋白委员会委员，河南省食品工业协会食品质量安全分会副秘书长，河南省营养学会理事，美国化学学会（ACS）会员。

教育与工作经历

教育经历：1989.9-1994.6 河南医科大学 预防医学系，医学学士

2000.9-2003.6 西北农林科技大学 食品科学专业 工学硕士

2003.9-2007.3 江南大学  食品营养与安全 工学博士

研究工作经历

1994.7-2003.9 河南科技学院 食品学院 讲师

2007.4-2013.11河南工业大学 粮油食品学院  副教授

2013.12-至今 河南工业大学 粮油食品学院  教授

      2016.12-2017.12 美国新泽西州立大学（Rutgers University）访问学者

研究领域与方向

1.真菌毒素降解酶的挖掘及生物合成

2.食品功能性因子挖掘及生物制造

教授课程

本科生：《食品营养学》《食品质量管理与控制》；研究生：《高级营养学》

研究成果

（一） 主要科研项目

    1.主持国家自然科学基金联合基金重点项目《黄曲霉毒素微生物源耐热降解酶挖掘及酶学基础研究》（No.U24A20473）（2025.01-2028.12）

2.主持国家自然科学基金《pH协同热处理对黑豆花青素结构及抗氧化活性影响的分子机制研究》（No. 31972003）（2020.01-2023.12）

3.主持国家自然科学基金项目《壁材对微胶囊物化性质及与载体混合动态行为的影响机理》（No. 31271840）（2013.01-2013.12）

4.主持河南省重点研发专项项目《食品加工全程中真菌毒素污染控制关键技术研发与应用》（No.231111113300）（2023.08-2026.12）

5.主持2020年河南省高校科技创新团队《食品营养安全检测与控制》（No. 20IRTSTHN023）（2020.01-2022.12）

6.主持2020年郑州市重大科技创新专项《粮油食品加工过程中真菌毒素控制关键技术研发及应用》（No. 2020CXZX0077）（2020.10-2023.12）

7.主持河南省科技厅重点科技攻关4项（No. 192102310254，No. 162102210039等）

8.参与“十三五”国家重点研发计划项目《食品加工过程中组分结构变化及品质调控机制研究》（No.2016YFD0400200）（2016.10-2021.09） 

（二）代表著作与论文

1. Hongxin Zhang, Shujie Zhang, Antonio Francesco Logrieco, Giuseppina Mule, Yuhui Yang, Yabo Liang, Hang Jia, and Yanli Xie*. Engineering Laccase from Aspergillus terreus HNGD-TM15 with Enhanced Catalytic Activity and Thermostability for the Degradation of Aflatoxin B₁ and Zearalenone. Journal of Agricultural and Food Chemistry, 2026, 74 (22): 17423-17437.（中科院一区TOP）

2. Hongxin Zhang, Shujie Zhang, Nazish Muzaffar, Antonio Francesco Logrieco, Giuseppina Mule, Yuhui Yang, Weibin Ma, Yabo Liang, and Yanli Xie*. Enhancing the Thermostability and Catalytic Activity of a Multicopper Oxidase from Bacillus megaterium for Aflatoxin B1 and Zearalenone Degradation. Journal of Agricultural and Food Chemistry, 2026, 74 (18): 14583-14598.（中科院一区TOP）

3. Minjie Hou, Nazish Muzaffar, Yanli Xie*, Qingrong Huang, Yuhui Yang, and Guanhong Chang. Mechanism and Application of Thermostable Superoxide Dismutase from Alcaligenes faecalis HNGD-HTN06 to Degrade AFB1/ZEN. Journal of Agricultural and Food Chemistry, 2026, 74 (3): 3081-3100.（中科院一区TOP）

4. Yuhui Yang, Yanli Xie*, Ru Liu, Xiaojie Cui, Changtong Cui, Qiaofen Cheng, Peng Li, Renyong Zhao. Characteristic of different thermal treatment-induced dough protein oxidation and its impact on human gut microbiota. Current Research in Food Science, 2026, 12: 101357.（中科院一区TOP）

5. Yuhui Yang, Yanli Xie*, Manman Lu, Yuncong Xu, Renyong Zhao. Contribution of dietary methionine to gut health and its related diseases: implications for precision nutrition. Critical Reviews in Food Science and Nutrition, 2026, 66(3): 565-588.（中科院一区TOP）

6. Hongxin Zhang, Shujie Zhang, Weibin Ma, Yuhui Yang, Xiao Li, Yanli Xie*. Amphiphilicity and thermostability modification of dipeptidyl peptidase III from aspergillus terreus HNGD-TM15 capable of simultaneously degrading aflatoxin B 1 and zearalenone. Food Chemistry, 2025, 496: 146807.（中科院一区TOP）

7. Nazish Muzaffar, Weibin Ma, Yuhui Yang, Qian Li, Hang Jia, Renyong zhao, Yanli Xie*. Bacillus amyloliquefaciens HNGD-DF2 from Chinese Tofu: A potential thermophilic agent for AFB 1 and ZEN degradation in wheat and maize. Food Control, 2025, 172: 111178. （中科院一区TOP）

8. Ranran Ma, Muzaffar Nazish, Wei Xu, Hang Jia, Yabo Liang, Guanhong Chang, Yuhui Yang, and Yanli Xie*. Functional Characterization and Mechanism of Two Aflatoxin B1-Degrading Enzymes from Pseudomonas aeruginosa HNGD-JZ06. Journal of Agricultural and Food Chemistry, 2025, 73: 29886-29899.（中科院一区TOP）

9. Ranran Ma, Weiwei Peng, Yanli Xie*, Muzaffar Nazish, Weibin Ma, Yuhui Yang, Qian Li, Hang Jia. Mechanistic Insights into Aflatoxin B1 and M1 Degradation by Bacillus subtilis HNGD-Mq02 from Wheat Koji and Its Application in Food Detoxification. Journal of Agricultural and Food Chemistry, 2025, 73 (36), 22808-22821.（中科院一区TOP）

10. Minjie Hou, Xuedong Mei, Mwabulili Fred, Qian Li, Hang Jia, Qingrong Huang, Yanli Xie*. Identification of an M20 Family Metallopeptidase with Amidohydrolase Activity from Alcaligenes faecalis HNGD-HTN06 and Simultaneous Degradation of Ochratoxin A, Aflatoxin B1, and Zearalenone. Journal of Agricultural and Food Chemistry 2025, 73(36), 22822-22837.（中科院一区TOP）

11. Mengdan Ku, Jiajun Li, Wenhao Zhang, Shumin Sun*, Yaqi Zhang, Yanli Xie*. Degradation of AFB₁ in edible oil by aptamer-modified TiO₂ composite photocatalytic materials: Selective efficiency, degradation mechanism and toxicity. Food Chemistry, 2025, 470, 142674.（中科院一区TOP）

12. Jinghao Shi, Fred Mwabulili, Yanli Xie*, Yuhui Yang, Shumin Sun, Qian Li, Weibin Ma, Hang Jia. Characterization, Structural Analysis, and Thermal Stability Mutation of a New Zearalenone-Degrading Enzyme Mined from Bacillus subtilis. Journal of Agricultural and Food Chemistry 2024, 72 (6), 3025-3035.（中科院一区TOP）

13. Hongxin Zhang, Lanbin Cui, Yanli Xie*, Xiao Li, Renyong Zhao, Yuhui Yang, Shumin Sun, Qian Li, Weibin Ma, Hang jia. Characterization, Mechanism, and Application of Dipeptidyl Peptidase III: An Aflatoxin B₁-Degrading Enzyme from Aspergillus terreus HNGD-TM15. Journal of Agricultural and Food Chemistry 2024,72(28):15998-16009.（中科院一区TOP）

14. Fred Mwabulili, Yanli Xie*, Shumin Sun, Weibin ma, Qian Li, Yuhui Yang, Hang jia, Xiao Li. Thermo-Alkali-Tolerant Recombinant Laccase from Bacillus swezeyi and Its Degradation Potential against Zearalenone and Aflatoxin B₁. Journal of Agricultural and Food Chemistry, 2024, 72(23), 13371-13381.（中科院一区TOP）

15. Yuhui Yang, Guifang Cui, Jing Qian, Yuncong Xu, Bowen Li, Yonghui Shi, Guowei Le, Yanli Xie*. Fecal microbiota transplantation from methionine-restricted diet mouse donors reduces fat deposition in obese mice by remodeling the gut microbiota. Food Bioscience, 2024, 59: 104255.（中科院一区TOP）

16. Sizhong Cheng, Tian Wu, Hongxin Zhang, Zhongke Sun, Fred Mwabulili, Yanli Xie*, Shumin Sun, Weibin Ma, Qian Li, Yuhui Yang, Hang Jia. Mining Lactonase Gene from Aflatoxin B(1)-Degrading Strain Bacills megaterium and Degrading Properties of the Recombinant Enzyme. Journal of Agricultural and Food Chemistry 2023, 71 (51), 20762-20771.（中科院一区TOP）

17. Yang, Yuhui, Manman Lu, Jing Qian, Yuncong Xu, Bowen Li, Guowei Le, Yanli Xie*. Dietary Methionine Restriction Promotes Fat Browning and Attenuates Hepatic Lipid Accumulation in High-Choline-Fed Mice Associated with the Improvement of Thyroid Function. Journal of Agricultural and Food Chemistry, 2023, 71(3): 1447-1463.（中科院一区TOP）

18. Yuhui Yang, Manman Lu, Jing Qian, Yuncong Xu, Bowen Li, Guowei Le, Yanli Xie*. Dietary methionine restriction promotes fat browning and attenuates hepatic lipid accumulation in high choline-fed mice associated with the improvement of thyroid function. Journal of Agricultural and Food Chemistry, 2023, 71(3): 1447-1463.（中科院一区）

（三）第一发明人授权发明专利

1.一种高效降解黄曲霉毒素B1的菌株及其应用.2020.11, 国家授权发明专利，专利号：ZL202010078383.X

2.一种同时降解呕吐毒素和玉米赤霉烯酮的贝莱斯芽孢杆菌及应用.2023.11,专利号：ZL 202210942045.5；

3.一株高效降解黄曲霉毒素B1和玉米赤霉烯酮的巨大芽孢杆菌及其应用、菌制剂.2023.10,专利号：ZL202211168173.5；

4.一株耐高温高效降解玉米赤霉烯酮和呕吐毒素的枯草芽孢杆菌及其菌剂.2023.12,专利号：ZL202210948162.2；

5.一种黄曲霉毒素定量检测试剂盒及其检测方法.2020.11, 国家授权发明专利，专利号：201810132052.2

6.一种检测黄曲霉毒素B1的比色法.2024.9，国家授权发明专利，专利号：ZL202111093575.9

7. 一种同时降解黄曲霉毒素B1和玉米赤霉烯酮的二肽基肽酶DPP Ⅲ、编码基因及其应用, 国家发明专利.2025.11, 国家授权发明专利，专利号：ZL202410802661.X

奖励与荣誉

1.河南省特聘教授；

2.河南省高层次人才；

3.第十四届郑州市十大科技女杰.

实验室和科研团队简介

所在的科研团队：食品营养与安全控制创新团队，是河南工业大学食品安全与营养方向的核心科研团队，深耕食品营养与安全控制领域，多年来主要围绕食品生产全程中有害物质控制和营养物质保护为目标，从事真菌毒素降解酶的生物合成及酶催化、光催化降解机制及技术、天然产物抑菌机制及产品开发、功能活性组分挖掘及慢病防控、功能性益生菌的筛选及产品开发六大重要方向开展有组织的基础及产业化研究。